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Beschreibung

Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether.

Mitwirkende

Autor Sanjeev Kumar Shukla

Autor Ramesh Chandra

Autor S. K. Puri

Produktdetails

DUIN 13BSQUT7CB4

GTIN 9783848433971

Sprache Englisch

Seitenanzahl 64

Produkttyp Taschenbuch

Größe 220  mm

Heam Polymerization and its Inhibition by Antimalarial Drug

Hemozoin is considered to be a suitable target to develop new antimalarial drug

Sanjeev Kumar Shukla

CHF 45.95

Verkäufer: Dodax

Lieferdatum: Mittwoch, 8. April

Zustand: Neu

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