Peristence of foot-and-mouth disease virus in cattle

von Kumar, Naveen
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Kumar, Naveen Peristence of foot-and-mouth disease virus in cattle
Kumar, Naveen - Peristence of foot-and-mouth disease virus in cattle

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Beschreibung

In the present study baculovirus expressed non-structural-protein (NSP) 3A of FMD virus (FMDV) was used to develop an indirect ELISA for differentiation of FMDV infected and vaccinated animals (DIVA). Using this test, field sera (from Haryana, India) were tested where a significant reduction (P<0.05) in the carrier animals (anti-NSP antibody positive) was observed 2 years after launching FMD control programme in the state. Interestingly, population of carrier cattle was found significantly (P<0.01) higher than buffaloes. Additionally, homologous and heterologous vaccine challenge experiments (HoCEs, HtCEs) were performed with FMDV AIraq22 and AIran96. In HoCEs, animals were completely protected (PD50>32). In 1st HtCE (AIraq22 vaccine/AIran96 challege virus), the vaccine offered good protection (PD50>6) but the vice versa of vaccine and challenge virus in 2nd HtCE could not offer protection (PD50<2). High potency vaccine was found to reduce the carrier state in HoCE but in HtCEs, inspite of giving good protection in certain cases, it could not prevent the development of carrier state.

Mitwirkende

Autor:
Kumar, Naveen

Weitere Informationen

Medientyp:
Taschenbuch
Verlag:
LAP Lambert Academic Publishing
Biografie:
Dr. Naveen Kumar was born in Dhakla (Jhajjar), Haryana of India. He studied in CCS Haryana Agricultural University, Hisar (India) where he successfully completed two degrees: a M.Sc. in Biotechnology & Molecular Biology in 2010, and Ph.D. in Molecular Biology and Biotechnology, which was achieved in 2014.
Sprache:
Englisch
Seitenanzahl:
132

Stammdaten

Produkttyp:
Taschenbuch
Verpackungsabmessungen:
0.22 x 0.15 x 0.008 m; 0.245 kg
GTIN:
09783659229435
DUIN:
18F0JBRPDOA
CHF 59.50
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