Biomarkers for Immunotherapy of Cancer - Methods and Protocols

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Springer US Biomarkers for Immunotherapy of Cancer - Methods and Protocols
Springer US - Biomarkers for Immunotherapy of Cancer - Methods and Protocols

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Beschreibung

This book provides the immune oncology (IO) community with a deeper understanding of the scope of the biomarker methods to potentially improve the outcome from immunotherapy. The editors secured the input from experts in the field dedicated to translating scientific research from bench to bedside was submitted. The book provides not only details about the technical, standardization and interpretation aspects of the methods but also introduces the reader to the background information and scientific justification for selected biomarkers and assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Weitere Informationen

Anmerkung Illustrationen:
XVIII, 733 p. 119 illus., 111 illus. in color.
Sprache:
Englisch
Inhaltsverzeichnis:
Part I: Scientific Questions and the Status of Inhibitory Receptors for Immunotherapy

1. Status of Immune-oncology: Challenges and Opportunities



Alessandra Cesano, Francesco M Marincola, and Magdalena Thurin



 



2. Immunological Targets for Immunotherapy: Inhibitory T Cell Receptors



Diwakar Davar and Hassane M. Zarour



 



Part II : Mutational and Germline Profiling

3. Measuring Tumor Mutational Burden Using Whole Exome Sequencing



Tomas Vilimas




 



4. Germline Genetics in Immuno-Oncology: From Genome-wide to Targeted Biomarker Strategies



Tomas Kirchhoff and Robert Ferguson



 



5. Detection of Microsatellite Instability Biomarkers via Next-generation Sequencing



Russell Bonneville, Melanie A. Krook, Hui-Zi Chen, Amy Smith, Eric Samorodnitsky, Michele R. Wing, Julie W. Reeser, and Sameek Roychowdhury




 



6. Genetic Instability Markers in Cancer



Giuseppe Palmieri, Milena Casula, Antonella Manca, Grazia Palomba, Maria Cristina Sini, Valentina Doneddu , Antonio Cossu, and Maria Colombino



 



7. Validation of Circulating Tumor DNA Assays for Detection of Metastatic Melanoma



Mahrukh M Syeda, Jennifer M. Wiggins, Broderick Corless, Cindy Spittle, George Karlin-Neumann, and David Polsky



 



8. Techniques Associated with Exosome Isolation for Biomarker Development – Liquid Biopsies for Ovarian Cancer Detection



Shayna Sharma and Carlos Salomon



 



Part III: Epigenetic Profiling

9. Identifying MicroRNA Pathway Variants as Biomarkers of Patient Selection for Immune Therapy



Joanne B. Weidhaas



 



10. Histone Modifications as Biomarkers for Immunotherapy



Erin M. Taylor, Brian Koss, Lauren E. Davis, and Alan J. Tackett



  Part IV: Functional Genomic Profiling

11. Functional Genome Profiling to Understand Cancer Immune Responsiveness



 Ena Wang, Davide Bedognetti, and Francesco M Marincola



 



12. Using RNA-sequencing to Characterize the Tumor Microenvironment



Smith CC, Bixby LM, Miller KL, Selitsky SR, Bortone DS, Hoadley KA, Vincent BG, and Serody JS



13. Development of Gene Expression Based Biomarkers on the nCounter® Platform for Immuno-Oncology Applications



Sarah Warren, Patrick Danaher, Afshin Mashadi-Hossein, Lynell Skewis, Brett Wallden, Sean Ferree, and Alessandra Cesano



 



14. The CRISPR System and Cancer Immunotherapy Biomarkers



Vitaly Balan and Jianbin Wang




           



Part V: Phenotyping of Tumor and Immune Cells

15. HLA Class I Antigen Processing Machinery Defects in Cancer Cells - Frequency, Functional Significance and Clinical Relevance with Special Emphasis on their Role in T cell-based Immunotherapy of Malignant Disease



Barbara Seliger and Soldano Ferrone



 



16. High-parameter Immune Profiling with CyTOF



Bita Sahaf, Adeeb Rahman, Holden T. Maecker, and Sean Bendall




 



17. The Adaptome as Biomarker for Assessing Cancer Immunity and Immunotherapy



Jian Han and Michael T. Lotze




 



18. Single Molecule Arrays for Ultrasensitive Detection of Blood-based Biomarkers for Immunotherapy 



Limor Cohen, Alissa Keegan, and David R Walt



 



19. Single-cell Multiplexed Proteomics on the IsoLight Resolves Cellular Functional Heterogeneity to Reveal Clinical Responses of Cancer Patients to Immunotherapies



Dong Liu, Patrick Paczkowski, Sean Mackay, Colin Ng, and Jing Zhou



 



20. Methods to Detect Immunogenic Cell Death in vivo



Takahiro Yamazaki, Aitziber Buqué Martinez, Marissa Rybstein, Jonathan Chen, Ai Sato, and Lorenzo Galluzzi



 



Part VI: Tissue Imaging Methods 

21. Overview of Tissue Imaging Methods



Sanjay S. Patel and Scott J. Rodig



 



22. Multiplex Immunofluorescence Assays



Alejandro Francisco-Cruz, Edwin Roger Parra, Michael T. Tetzlaff, and Ignacio I. Wistuba,



 



23. Multiplexed Immunohistochemical Consecutive Staining on Single Slide (MICSSS): Multiplexed Chromogenic IHC Assay for High-Dimensional Tissue Analysis



 



Guray Akturk, Robert Sweeney, Romain Remark , Miriam Merad, and Sacha Gnjatic

 



24 Cyclic Multiplexed-Immunofluorescence (cmIF), A Highly Multiplexed Method for Single-cell Analysis



Jennifer Eng, Guillaume Thibault, Shiuh-Wen Luoh, Joe W. Gray, Young Hwan Chang, and Koei Chin



 



25. High-Plex Spatially Resolved RNA and Protein Detection using Digital Spatial Profiling: A Technology Designed for Immuno-Oncology Biomarker Discovery and Translational Research



Joseph M. Beechem




 



26. The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples



Mael Manesse, Katir K. Patel, Sean R. Downing, andMark Bobrow



 



Part VII: Microbiome

27. Microbiome as an Immunological Modifier



Manoj Kumar, Parul Singh, Selvasankar Murugesan, Marie Vetizou, John McCulloch, Jonathan H. Badger, Giorgio Trinchieri, and Souhaila Al Khodor



  Part VIII: System Biology for Multi-platform Data Integration 28. Systems Biology for Multi-Platform Data Integration - Overview

Elad Ziv



 

29. Bioinformatics Tools and Resources for Cancer Immunotherapy Study



Alida Palmisano, Julia Krushkal, Ming-Chung Li, Jianwen Fang, Dmitriy Sonkin, George Wright, Laura Yee, Yingdong Zhao, Lisa McShane



 



30. Multiplatform Integrative Analysis of Immunogenomic Data for Biomarker Discovery



Vésteinn Thorsson




Part IX: Regulatory Perspective

31. Translating Immuno-Oncology Biomarkers to Diagnostic tests:  A Regulatory Perspective



You Li, Janaki Veeraraghavan, and Reena Philip



Auflage:
1st ed. 2020
Seitenanzahl:
733
Herausgeber:
Thurin, Magdalena;Thurin
Cesano, Alessandra;Cesano
Marincola, Francesco M.;Marincola
Bemerkungen:
Includes cutting-edge methods and protocols


Provides step-by-step detail essential for reproducible results


Contains key notes and implementation advice from the experts

Medientyp:
Taschenbuch
Verlag:
Springer US

Stammdaten

Produkttyp:
Taschenbuch
Verpackungsabmessungen:
0.254 x 0.178 x 0.04 m;
GTIN:
09781493997756
DUIN:
1I98JE3H9R2
CHF 154.15
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