The drug ±3,4-methylenedioxymethamphetamine (MDMA or ecstasy)is a popular recreational substance among young people. Most priorresearch has not attempted to carefully emulate human ecstasy usepatterns in animal investigations. The objectives of the presentseries of experiments were to develop a rat model of intermittentecstasy use and to begin to characterize the acute and long-termphysiological, behavioral, and neurochemical consequences ofadolescent MDMA exposure. These studies determined that: 1)repeated exposure to a clinically relevant MDMA dose can reducecognitive function and alter affective behavior, 2) adolescent MDMAcan lead to MDMA tolerance in adulthood, 3) the behavioraltoxicology of MDMA may not be exclusively mediated by decreases inthe serotonin transporter. Overall, these findings indicate thatthe enduring neurobiological consequences of MDMA may not belimited to the serotonergic system and have substantial publichealth implications for regular ecstasy users.
Neurobehavioral consequences of adolescent MDMA exposure in rats
Effects on Attention, Learning, Memory, Anxiety, Aggression, Physiology, and Neurochemistry