DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES

von Singh, Vandana
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CHF 49.95
inklusive MwSt. - GRATIS LIEFERUNG
Singh, Vandana DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES
Singh, Vandana - DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES

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Beschreibung

Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.

Mitwirkende

Autor:
Singh, Vandana
Chaudhary, Amrendra
Ahmed, Shamim

Weitere Informationen

Biografie:
Mrs. Vandana Singh graduated from Dr.K.N.M.I.P.E.R, Modinagar, and post graduated from Bundelkhand University, Jhansi. She is having 1 year of industrial and 4 years of teaching experience. Currently working as Senior Lecturer at Translam Institute of Pharmaceutical Education and Research, Meerut, India.
Sprache:
Englisch
Seitenanzahl:
92
Medientyp:
Taschenbuch
Verlag:
Dictus Publishing

Stammdaten

Produkttyp:
Taschenbuch
Verpackungsabmessungen:
0.22 x 0.15 x 0.005 m; 0.186 kg
GTIN:
09783844393682
DUIN:
L2S6FF7M3L0
CHF 49.95
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