Development of Novel Indolyl-derived Biologically Active Compounds

von El Sayed, Mardia
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El Sayed, Mardia Development of Novel Indolyl-derived Biologically Active Compounds
El Sayed, Mardia - Development of Novel Indolyl-derived Biologically Active Compounds

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Beschreibung

MRSA is a methicillin-resistance Staphylococcus aureus and a strain of Staphylococcus aureus that developed resistance to the killing effect of the beta-lactam antibiotics, which include the penicillins (methicillin, dicloxacillin, oxacillin, etc.), MRSA is sometimes called a "superbug" because it is very difficult to treat and it causes a huge number of infections every year in hospitals all over the world. The novel synthesized indoles will add a valuable new addition to the antibacterial arsenal for MRSA infections, it would be new bactericidal agents effective against resistant isolates or standard. We have shown for the first time that the cycloalkanoindoles,bis-indolobenzocarbazoles and the oxidized bis-indolylmethenes inhibited growth of drug resistant MRSA either standard or isolate and other Gram-positive bacteria at low concentrations. Some of these novel bis- and tris-indolyl compounds described in this work have been screened in the national cancer institute (NCI) in USA for one and five dose that showed the highest antipoliferative activity in a nanomolar scale towards the selected cancers cell lines (Non small lung: NCIeH460, Ovarian: OVCAR-4 and Breast: MCF).

Mitwirkende

Autor:
El Sayed, Mardia

Weitere Informationen

Biografie:
Author is Dr/Mardia Telep El Sayed, Egyptian researcher at National Research Centre, Applied Organic Chemistry Department. In 2009 she started her PhD scholarship in Synthetic Organic Chemistry/ Martin Luthr University Halle/ Germany and recieved her PhD in April 2013. She has BSc and MSc in Organic Chemistry from Egyptian Universties.
Sprache:
Englisch
Seitenanzahl:
312
Medientyp:
Taschenbuch
Verlag:
LAP Lambert Academic Publishing

Stammdaten

Produkttyp:
Taschenbuch
Verpackungsabmessungen:
0.22 x 0.15 x 0.018 m; 0.513 kg
GTIN:
09783659320712
DUIN:
CNHHO58NAQC
CHF 87.20
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