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Heterocycles in Organic Synthesis: Their Synthesis and Applications - Synthesis of Novel Heterocycles and Unnatural Glycosyl Amino Acids with their Biochemical and Pharmaceutical Studies and Applications

von Barghash, Reham F.
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CHF 83.05
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Barghash, Reham F. Heterocycles in Organic Synthesis: Their Synthesis and Applications - Synthesis of Novel Heterocycles and Unnatural Glycosyl Amino Acids with their Biochemical and Pharmaceutical Studies and Applications
Barghash, Reham F. - Heterocycles in Organic Synthesis: Their Synthesis and Applications - Synthesis of Novel Heterocycles and Unnatural Glycosyl Amino Acids with their Biochemical and Pharmaceutical Studies and Applications

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Beschreibung

Based on the recorded pharmacological potencies of numerous substituted pyrimidines as antihyperlipemic and antihypertensive agents, synthesis of condensed and spiro bis-heterocyclic systems; oxazole-pyrimidines as well as pyrimido-oxazines; bearing a phosphonate substituent was undertaken. The bioassay indicated that some of the products have effect on the central nervous system (CNS), and other products have good selective anti-tumor activity and the structure-activity relationship (SAR) of new phosphonates has also been indicated. In addition, a new class of C-glycosyl amino acids bearing a thiourea segment as a linker has been designed and synthesized by addition of glycosylmethyl isothiocyanates to an amine-functionalized amino acid. The orthogonal set of protective groups makes these compounds suitable substrates for the co-translational modification of natural peptides. The study included the synthesis of a set of new sugar isothiocyanates and their coupling with the alanine derivative.

Mitwirkende

Autor:
Barghash, Reham F.

Weitere Informationen

Biografie:
Reham F. Barghash (born in Cairo, Egypt). At present, she is a Researcher at National Research Centre (NRC), Egypt; spent 2 years in Italy at Ferrara Univ. as Associate Researcher; received NRC award for the best Ph.D. thesis 2009. Her research interests in chemistry provide new products for biochemical and pharmaceutical studies and applications.
Sprache:
Englisch
Seitenanzahl:
232
Medientyp:
Taschenbuch
Verlag:
LAP Lambert Academic Publishing

Stammdaten

Produkttyp:
Taschenbuch
Verpackungsabmessungen:
0.22 x 0.15 x 0.013 m; 0.395 kg
GTIN:
09783843378444
DUIN:
ME5153LSV9H
CHF 83.05
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